INFLUENCE OF ZINC DEFICIENCY ON METABOLISM OF VITAMIN A IN RATS / 营养学报

ABSTRACT

The study includes 2 experiments. Experiment 1 24 male weanling Wistar rats were divided into 3 groups, with 8 rats in each groupzinc-deficient group (ZD), pair-fed group (PF), zinc-sufficient group (ZS). The experiment term was 30 days, and the items observed were feed intake, body weight, serum zinc, tibia zinc, serum vitamin A and liver vitamin A. The results showed that Zn-deficient rats could not mobilize liver vitamin A into their blood normally. Experiment 2; 40 male weanling Wistar rats were raised with Zn-deficient feed for 30 days, then they were divided into 4 groups randomly, keeping 7 rats in each groupZn-deficient group (ZD), Zn-treatment group I(ZT1), Zn-treatment group II(ZT2), Zn-treatment group III(ZT3), their daily Zn dosages were 0.63 umol, 1,89 umol, 3.80 umol respectively. The treatment lasted for 6 days. The results demonstrated that serum zinc and vitamin A concentrations of the 3 Zn-treated groups were much higher than that of ZD group. In contrast, their liver vitamin A concentrations were much lower than that of ZD group.