EFFECTS OF 7-BROMETHYOXYBENZENTETRAHYDROPALMATINE ON GUINEA PIG PAPILLARY MUSCLES AND ATRIUM / 中国药理学通报

ABSTRACT

7-Bromethyoxybenzentetrahydropalmatine ( EBP) possessed antiarr-hythmic effect in several animals models.The authors studied the direct influence of EBP on the automaticity, refractory period, excitability and the contractility of isolated papillary muscle and atrium of guinea pig.EBP was found to decrease the automaticity and prolong the functional refractory period and increase the contractility of guinea pig papillary muscle, but it exerted no influence on its excitability.The decrease in automoticity and prolongation of refractory period was thought to be ascribed to its antiarrhythmic action.