Hyperfractionated high dose rate interstitial brachytherapy for carcinoma of the oral cavity and orophanynx / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology
;
(6)1992.
Article
Dans Chinois
| WPRIM
| ID: wpr-552390
ABSTRACT
Objective To study the results of external beam radiotherapy plus 192 Ir hyperfractionated high dose rate interstitial brachytherapy (HHDR-IBT) for cancer of the oral cavity and oropharynx. Methods Fourty-eight patients with cancer of the oral cavity and oropharynx were treated by external beam radiotherapy (T 1,T 2 30~50 Gy,T 3,T 4 50~60 Gy) followed by 192 Ir HHDR-IBT delivering 15~35 Gy (30~35 Gy for T 1,T 2 and 15~30 Gy for T 3,T 4 in 250~350 cGy per fraction,two fractions per day). Over 3~5 days. Results The complete response rates at 3 months were T 1100% (5/5),T 2 85%(23/27),T 3 46%(6/13),T 4 0%(0/3) and the partial reponse ratesT 2 15% (4/27), T 3 54%(7/13), T 4 100%(3/3). The 3-year survival and disease-free survival rates were 79.4% and 55.8%,respectively.Multivariate analysis showed that TNM stage and pathalogic type were prognostic factors.Conclusions Carcinoma of the oral cavity and oropharynx treated with external beam radiotherapy combined with 192 Ir hyperfractionated high dose rate interstitial brachytherapy ia able to give a good local control for T 1,T 2 lesions with good functional preservation. For T 3,T 4 lesions,this method is able to offer a high palliation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
Chinese Journal of Radiation Oncology
Année:
1992
Type:
Article
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