A STUDY OF TUROMBIN APTAMER AS AN ADJUNCT IN ACCELERATING THROMBOLYSIS WITH UROKINASE / 解放军医学杂志

ABSTRACT

On the basis of superimposed stenosis, a model of femoral occlusive thrombus was produced in 12 dogs. Among them, urokinase+saline were given in 6 dogs (group A), aptamer was given ten minutes before urokinase in another 6(group B). The aim of the study was to explore the effect of a new direct sited thrombin inhibitor thrombin aptamer on thrombolysis . The results showed that the interval between thrombosis and reflow was significantly different between this two groups ( P