Bcl-2 AND P53 EXPRESSION IN RENAL CELL CARCINOMA: p53 OVEREXPRESSION IS AN INDEPENDENT PROGNOSTIC PARAMETER / 解放军医学杂志

ABSTRACT

To elucidate Bcl 2 and P53 protein expression in renal cell carcinoma(RCC) and their patho clinical significance, the expression of Bcl 2 and P53 proteins was evaluated immunohistochemically and compared with the patho clinical factors from 113 patients. The Bcl 2 positivity was demonstrated in 52 cases(46 0%), but no significant correlation with patho clincal factors could be found. 30 cases (26 5%) were positively stained for P53 protein. P53 overexpression was frequently detected in patients with lymphonode or distal metastases ( P =0 047 and P