Effect of Metformin Treatment and Insulin Resistance in Patients with Polycystic Ovary Syndrome / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1949-1953, 2004.
Article
Dans Coréen
| WPRIM
| ID: wpr-55332
ABSTRACT
OBJECTIVE:
This study was performed to investigate the effect of metformin treatment and insulin resistance in the patients with polycystic ovary syndrome.METHODS:
Twenty three patients with polycystic ovary syndrome were included at Seoul National University Hospital from September 2001 to September 2003. Metformin was administered at daily 1,500 mg for 3 months to these patients. Then restoration of regular menstruation or recovery of ovulation was evaluated and insulin resistance was compared between the responder and the non-responder before and after metformin treatment.RESULTS:
Eleven patients (47.8%) showed a significant improvement in menstrual or ovulation cyclicity whereas twelve patients had no change. There was no statistically significant difference in the insulin resistance between the responder and the non-responder before and after metformin treatment.CONCLUSION:
In non-obese patients with polycystic ovary syndrome, metformin treatment seems to be effective to improvement of menstrual or ovulation cyclicity irrespective of insulin resistance expressed as glucose-to- insulin ratio and HOMA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ovulation
/
Périodicité
/
Syndrome des ovaires polykystiques
/
Insulinorésistance
/
Séoul
/
Insuline
/
Menstruation
/
Metformine
Limites du sujet:
Femelle
/
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2004
Type:
Article
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