Effect of hesperidin on locomotor activity of mice with infective brain injury induced by LPS / 重庆医学

ABSTRACT

Objective To study the effect of hesperidin on the locomotor activity of mice with infective brain injury induced by li-popolysaccharide (LPS)in the dark field environment.Methods 45 ICR mice were randomly divided into 3 groupsSaline group, LPS group and LPS+Hesperidin group,15 mice in each group.The moving distance and the number of crossing line in the dark field were recorded using the ZH-ZFT locomotor activity video analysis system.ResultsThe LPS group had significantly shorter moving distance as well as lower frequency of the number of crossing line than those of the Saline group(P<0.05);compared with the LPS group,the Hesp group moved longer and crossed line more frequently,the differences between the two groups had statisti-cal significance (P<0.05).Conclusion Hesperidin could significantly improve the capacity for action in the dark field of mice with infective brain inj ury induced by LPS.