Effects of different penetration enhancer on penetration of ciclopirox olamine and salysic acid in percutaneous penetration / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2000.
Article
Dans Chinois
| WPRIM
| ID: wpr-553569
ABSTRACT
AIM:
To study the enhancing effect of penetration enhancer on percutaneous absorption of antifungal agents.METHODS:
Percutaneous penetration experiment was performed on device in vitro, and the deposit effects were observed with vivoperception.RESULTS:
Combination of 1-menthol (1%) and azone (1%) showed the best effect on percutaneous absorption of cidopicox olamine, and 1-menthol (1%) had the best effect on percutaneous absorption of salysic acid. The compound penetration enhancer, consisting of 1-menthol (1%), azone (1%), propylene glycol ( 2.5%) and oleic acid ( 2.5%), had prominent action on absorption of cidopirox olamine through rabbit skins, and shorten the lag times obviously.CONCLUSION:
L-menthol and azone can significantly enhance the percutaneous absorption of both salysic acid and cidopicox olamine. Combination of 1-menthol and azone can further increase the absorption.c
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Clinical Pharmacology and Therapeutics
Année:
2000
Type:
Article
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