STUDY ON DYNAMIC CHANGES IN PLASMA NITRIC OXIDE AND ENDOTHELIN AND THERAPEUTIC EFFECT OF L-ARGININE ON TRAUMATIC SHOCK IN RATS / 解放军医学杂志

ABSTRACT

The purpose of this study was to evaluate the dynamic changes in nitric oxide(NO), endothelin(ET) and oxygen partial pressure in tissues in the pathogenesis of traumatic shock, and to explore the therapeutic effect of L-Arginine. Traumatic shock was produced in Sprague-Daulay rats, and they were randomly divided into shock group and treatment group. NO and ET were assayed in blood, muscles, liver and small intestine before and after shock. Meanwhile, hemodynamic data of the rats and their survival time were monitored and recorded. The data showed that plasma NO and ET levels were elevated significantly after traumatic shock. There was statistical significance in tissues oxygen partial pressure between pretrauma and postshock periods. Plasma ET levels of treatment group at 5,12h after resuscitation were significant lower than that of shock group, and NO/ET were higher after resuscitation than that of shock group. Oxygen partial pressure in the liver and small intestine of treatment group were significant higher after resuscitation than that of shock group, and their survival rates at 12,24h were higher than that of shock group(P