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Shikonin induce HeLa cell apoptosis via a caspase-dependent mechanism / 中国药理学通报
Article de Zh | WPRIM | ID: wpr-555015
Bibliothèque responsable: WPRO
ABSTRACT
AIM To study the mechanisms of shikonin-induced HeLa cell apoptosis. METHODS Cytotoxicity assay by MTT, DNA fragmentation assay, LDH activity-based cytotoxicity assay and Western blot analysis were carried out. RESULTS Shikonin inhibited HeLa cell growth in a dose- and time-dependent manner. Apoptotic cell death was observed within 24 h after 40 ?mol?L -1 shikonin treatment. Shikonin induced HeLa cell apoptosis involved in the activation of caspase-3 and caspase-8, which is similar to the Fas or TNF-? signaling transduction pathways. CONCLUSION Shikonin induced caspase-dependent apoptosis in HeLa cells.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Chinese Pharmacological Bulletin Année: 1986 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Chinese Pharmacological Bulletin Année: 1986 Type: Article