Efficacy of fluvastatin on high level of serum lipoprotein (a) in patients with type 2 diabetic nephropathy / 中国实用内科杂志

ABSTRACT

Objective To evaluate the efficacy of nuvastatin on the high level of serum lipoprotein(a) [Lp(a)] and itsclinical significance in patients with type 2 diabetic nephropathy. Methods In this study, 104 patients with microalbu-winuric type 2 diebetic h?phropathy) were divided into two groups randomly the flu vastatin. group (zomg per day P.O. )and the control group. The efficacy at 6 weeks' beatment was evaluated. The serum Lp(a) concentration and the activityof tissue-type plasminogen activator(tPA ) and plasminogen activator inhibitor(PAI) were measured by enzyme-linkedimmunosorbent assay and chromogenic substances assay respechtively in all of the patients. Results At the beginning. ser-um Lp(a ) level and PAI activity along with a low tPA activity were abnormally high in every patient. In addition, the levelof Ccr was unconventionally high. After 6 weeks,the level of serum Lp(a) and the activity of PAI and tPA were cowectedsignilicanily in the teated group compared with the other group(P