Effects of 1?,25-dihydroxyvitamin D_3 and UVB on cell proliferation and melanin synthesis of cultured human melanocyte / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6)2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-555560
ABSTRACT
Objective:
To study the effects of 1?,25-dihydroxyvitamin D 3 and UVB on cell proliferation and melanin synthesis of normal human melanocytes.Methods:
Melanocytes of foreskins of healthy men were cultured and treated with various concentration of 1?,25-dihydroxyvitamin D 3 or UVB (55 mJ/cm 2),or both.Cell proliferation was measured with MTT assay .The synthesis of melanin was determined by chromatography.Results:
1?,25-dihydroxyvitamin D 3 and UVB could promote the proliferation of cultured melanocyte,and 1?,25-dihydroxyvitamin D 3 could promote the melanin synthesis.The significant concentration of 1?,25-dihydroxyvitamin D 3 ranging from 10 -7 to 10 -10 mol/L.Conclusion:
1?,25-dihydroxyvitamin D 3 and UVB irradiation could promote the proliferation of melanocyte,which indicates that they might be effective in the treatment of vitiligo.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Peking University(Health Sciences)
Année:
2003
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS