Correlation of vascular endothelial growth factor gene polymorphism to diabetic nephropathy in type 2 diabetes mellitus / 中华肾脏病杂志

ABSTRACT

Objective To investigate the correlation of vascular endothelial growth factor (VEGF)-634G/C gene polymorphism to diabetic nephropathy in type 2 diabetes mellitus. Methods VEGF genotype was determined by PCR-RFLP in 98 healthy controls and 216 patients with type 2 diabetes including 104 cases without nephropathy and 112 cases with nephropathy. VEGF genotype and allele frequencies were compared among these groups.Results (1)Individuals with CC genotype had higher serum VEGF level than those with CG and GG groups. (2)The genotype CC distribution and C allele frequency in diabetic nephropathy were significantly higher than those in cases without nephropathy group and in controls. (3)Compared with genotype GG and CG class, the morbidity of diabetic nephropathy in genotype CC class was significantly increased. (4) Logistic regression analysis revealed that serum VEGF level and its CC genotype, SBP, HbA1C, LDL-C and BMI were important risk factors of type 2 diabetic nephropathy. Conclusions VEGF -634G/C polymorphism is associated with the development of type 2 diabetic nephropathy. C allele is probably a susceptible gene of type 2 diabetic nephropathy.