Determination method of CYP3A activity and individualization dosage regimen of etoposide / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-557404
ABSTRACT
AIM:
To explore the correlation between drug concentration of etoposide (VP16) and CYP3A activity (CA) in leukemia.METHODS:
The urinary 6?-hydroxycortisol/hydrocortisone ratio is a useful marker for CA. Concentration of VP16 in plasma and CA was determined by HPLC in 20 leucemia patients, and the correlation analysis was performed using the SPSS software.RESULTS:
Correlation analysis between drug concentration of VP16 and CA in leukemia was poor correlated (r = 0.725), but concentration of VP16 and lgCA showed a good correlated (r =0.969).CONCLUSION:
It is feasible to adjust the therapeutic regimen of VP16 by determining CA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Clinical Pharmacology and Therapeutics
Année:
2004
Type:
Article
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