Effects of anti-morphine vaccines on pharmacological actions of morphine in mice / 中国药理学通报

ABSTRACT

Aim To investigate the effects of anti-morphine vaccines on pharmacological actions of morphine in mice.Methods Morphine-6-succinyl and morphine were conjugated respectively with Blue Carrier(BC) in the presence of carbodi-imide.After being immunized with both vaccines(M-BC,M-6-S-BC),the withdrawal syndrome and the abirritation were observed in mice.Results The withdrawal syndrome of the immune mice with M-6-S-BC and M-BC vaccines were reduced markedly compared with the model group,the skipping times were decreased and the latency was longer(P