Relationship between hypertension and inflammation / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2000.
Article
Dans Chinois
| WPRIM
| ID: wpr-558189
ABSTRACT
Inflammatory processes appear to play an important role in the pathogenesis of cardiovascular diseases.It has been established that inflammation has a pivotal role in the atherosclerosis.As a major risk factor contributed to atherosclerosis,hypertension seems to be a chronically low-grade inflammation process.Lots of studies suggested that blood pressure elevation is significantly positive correlation with the levels of inflammatory mediators,such as C-reactive protein.Inflammation may promote the process of hypertension.Furthermore,inflammation is highly associated with cardiac fibrosis and vascular remodeling in hypertension.Current clinical trials,for example,ASCOT-LLA suggested that use atorvastatin to reduce the inflammatory reaction in hypertensive patients with normal concentration of cholesterol would decrease the major cardiovascular events(relative risk reduction 36%).This paper summarizes the association inflammation with hypertension as well as cardiac fibrosis and vascular remodeling,and tries to explore the clinical significance of the association.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
langue:
Chinois
Texte intégral:
Chinese Journal of Clinical Pharmacology and Therapeutics
Année:
2000
Type:
Article
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