Effect of Jian-wei decoction on the quality of ulcer healing and expression of EGFRmRNA in the rat model of gastric ulcer / 中国基层医药

ABSTRACT

Objective To investigate the the effect and mechanism of Jian-wei decoction(JWD) on quality of ulcer healing.Methods The rat models of chronic gastric ulcer were induced by acetic acid,the effects of QOUH of JWD on the model of gastric ulcer were observed,the expression of EGFRmRNA of mucosa were measured in situ hybridization.Results JWD could improve the injury of gastric mucosa and increase the expression of EGFRmRNA in the tissue around peptic ulcer(PU).Conclusion JWD increases the expression of EGFRmRNA in the tissue around PU which might be one of possible mechanisms that JWD improves quality of ulcer healing.