The best parameters in retinal nerve fiber layer thickness measured by optical coherence tomography in the early stage of glaucoma / 第三军医大学学报

ABSTRACT

Objective To determine the characteristics and the best parameters of the retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in the early diagnosis of primary open angle glaucoma (POAG). Methods The thickness of RNFL was quantified by OCT (Carl Zeiss Meditec, Stratus OCT3000 version 3, RNFL3.4) in 71 POAGs(119 eyes) and 76 controls(148 eyes). Results The 9 OCT parameters with the largest AUCs and asymptatic significance less than 0.05 in ROC curve in the early diagnosis of primary open angle glaucoma (POAG) were thickness of 6, 7, 11 o’clock position, inferior, superior, average thickness, inferior maximum, superior average, inferior average. Conclusion In early stage of glaucoma, the thickness of RNFL measured by OCT provides a new index for the diagnosis of glaucoma. The best parameters seem to 6, 7, 11 o’clock position, inferior, superior, average thickess, inferior maximum, superior average, inferior average.