The effect and mechanism of genistein on collagen synthesis of growth plate chondrocytes / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
de Zh
| WPRIM
| ID: wpr-559727
Bibliothèque responsable:
WPRO
ABSTRACT
Aim To investigate effects of genistein (5, 7, 4′-trihydroxyisoflavone) on rat costochondral growth plate chondrocyte (RGC) collagen and Sox9 expression. Methods Primary cultured RGC, effects of genistein on collagen synthesis, col2a1 mRNA transcription and Sox9 protein expression of 1st passage RGC were detected by isotope incorporation, RT-PCR and western blotting. Results Genistein inhibited collagen synthesis of 1st passage RGC (P
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Pharmacological Bulletin
Année:
2003
Type:
Article