Effect of OFR on small intestinal injury in rats exposed to sulfur mustard and burn / 第三军医大学学报

ABSTRACT

Objective To investigate the effect of oxygen free radical (OFR) on the injury of small intestine in rats treated with burn, sulfur mustard or sulfur mustard plus burn. Methods Totally 95 SD rats were randomly divided into four groups 30 rats subjected to 30 third-degree TBSA scalding (B), 30 injected subcutaneously with 2 ml/kg sulfur mustard (S), 30 subjected to both (SB), 5 as normal controls (C). Activity of diamine oxidase (DAO) and superoxide dismutases (SODs), contents of malonaldehyde (MDA) in plasma, and pathological changes of ileum at 2, 6, 12, 24, 48, 72 h after injury were observed. Results Three treatments could induce significant decrease of activity of SODs (P