Thyroperoxidase expression in fine needle aspirated thyroid tumor cells and it clinical relevance / 第二军医大学学报

ABSTRACT

Objective:To observe thyroperoxidase (TPO) expression in fine needle aspirated thyroid tumor cells and to assess the value of TPO immunostaining in differential diagnosis of benign and malignant thyroid tumors. Methods: Fine needle aspiration (FNA) samples and frozen tissue sections of 71 surgically resected thyroid tumor specimens were immunostained by with hTPO MoAb47. The staining results were considered positive if 80% or more thyroid cells were positively stained. Results: TPO expression levels in FNA samples and frozen tissue sections of malignant tumors were lower than those of benign tumors (P