Calcium homeostasis deregulation in glutamate-induced excitotoxicity and its role in neurodegenerative diseases / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
de Zh
| WPRIM
| ID: wpr-561162
Bibliothèque responsable:
WPRO
ABSTRACT
Excitotoxicity refers to a process of neuronal death caused by excessive or prolonged activation of receptors for the excitatory amino acids, which is related to the overload of intracellular calcium ([Ca2+]i) and mitochondrial depolarization. The well accepted hypothesis that Ca2+ plays a central role in neurotoxicity, and it mediated excitotoxicity is deeply involved in both acute and chronic neurodegeneration suggests that inhibitors of Ca2+ transduction, such as NMDA antagonists, might block the pathological process at an early stage and provide more effective protections.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Pharmacological Bulletin
Année:
1987
Type:
Article