Treatment of hydroxyurea(HU)combined chemotherapy in treating hyperleukocytosis acute leukemia(HAL) / 中国实用内科杂志

ABSTRACT

Objective To explore the effects of hydroxyurea(HU) combined chemotherapy in treating hyperleukocytosis acute leukemia(HAL).Methods All the 21 patients were divided into two groups randomly.The patients of experiment group were treated by HU,(0.1g tid po),continuing 3-7 days,along with allopurinol(200 mg tid po).The 18 patients of controlled group were treated only by chemotherapy.Results The results showed the majority(57.1%) patients were of completely remiss(CR),the proportions of partly remission(PR) and no remission(NB) were 19.0% and 23.8%.To- tal remission rate was 76.1%.Two patients died early(9.5%.In the controlled group,the rate of CR,PR,NR were 16. 7%,33.3%,and 50%.Four patients died early(22.4%).Conclusion The HU combined chemotherapy had higher re- mission rate than that of chemotherapy in treating HAL.