Effect of three volatile oils on percutaneous penetration of aconitine through mouse skin in vitro / 中华中医药杂志
China Journal of Traditional Chinese Medicine and Pharmacy
;
(12)2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-562812
ABSTRACT
Objective:
To study the effect of volatile oil of Fructus Litseae(FL) ,Rhizoma Zingiberis(RZ) and Rhizoma Acori Talarinowii(RAT) on percutaneous penetration of aconitine through mouse skin in vitro.Methods:
By using improved Franz diffusion cells,the effects of these 3 volatile oils on the percutaneous penetration of aconitine were observed and compared with azone,and the cumulative amount of aconitine was determined by HPLC.Results:
The penetration coefficient of aconitine with 7%(v/v) volatile oil of FL,RZ and RAT and 3% azone were 10.79,5.82,5.40,3.91,respectively;Compared with the group without penetration enhancers,the differences were significannt;and the enhancement ratios were 3.87,2.09,1.94 and 1.40,respectively,which showed the enhancement ratios of 7% of the 3 volatile oils were higher than that of 3% azone.Conclusion:
The 7% volatile oils of FL,RZ and RAT enhance the permeation of aconitine effectively.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Journal of Traditional Chinese Medicine and Pharmacy
Année:
2005
Type:
Article
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