Study on the action of IgG,IgM and IL-8 in the pathogenesis of microscopic colitis / 中国实用内科杂志

ABSTRACT

Objective To investigate the action of immune factors(IgG and IgM)and cytokine(IL-8)in the pathogenesis of microscopic colitis.Methods Immunohistochemical methods and radioimmune methods were used to detect IgG and IgM in intestinal mucosa and IL-8 in serum respectively.The data of 32 cases who were diagnosed as microscopic colitis were compared with that of 71 irritable bowel syndrome(IBS)and 38 active ulcerative colitis(UC)patients who were assigned as the control group.Results The expression of IgG and IgM increased in MC group;there were significant differences compared with IBS group,but no significant differences compared with UC group;the level of IL-8 in MC group showed significant difference compared with UC group but had no significant difference compared with IBS group;the level of IL-8 in UC group increased obviously.Conclusion It is the disordered function of immune system that plays a main roles in the pathogenesis of MC,not inflammation.