Effects of alanyl-glutamine dipeptide on postoperative intestinal permeability and stress response / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6)2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-564485
ABSTRACT
Objective:
The study was designed to observe the effects of alanyl-glutamine (Aln-Gln) dipeptide on postoperative intestinal permeability and stress response.Methods:
A prospective, randomized and controlled trial was taken. 20 patients who underwent abdominal surgery were randomized into two groups study group [intravenous administration of Aln-Gln dipeptide, 0.5 g/(kg?d), for 4 days, n=10 and control group (normal saline as placebo, for 4 days, n=10)]. Serum concentrations of glutamine (Gln), diamine oxidase (DAO), cortisol, interleukin-6(IL-6) and urine lactulose/mannito (L/M) ratio were measured before and after operation.Results:
Serum Gln concentration was significantly decreased in control group and increased in study group on postoperative day 5.Urine L/M ratio was significantly increased in control group and decreased in study group.The serum concentrations of DAO,cortisol and IL-6 were significantly decreased in study group while compared with control group.Conclusion:
Administration of Aln-Gln dipeptide can increase the level of serum Gln,decrease the intestinal permeability and attenuate the stress response in the early period of postoperative patients. Aln-Gln dipeptide can be used in the fast track surgery.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Essai clinique contrôlé
langue:
Chinois
Texte intégral:
Parenteral & Enteral Nutrition
Année:
2004
Type:
Article
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