The Effects of Unaggregated Amyloid ? Protein(25-35) on Transient Outward Potassium Current in Rat Hippocampal CA3 Pyramidal Neurons / 医学研究杂志
Journal of Medical Research
;
(12)2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-564509
ABSTRACT
Objective To investigate the effects of unaggregated amyloid ? protein(A?25~35) on transient outward potassium channel(IA) in Rat Hippocampal CA3 Pyramidal Neurons.Methods Patch-clamp technique with whole cell recording was used.Results Unaggregated A?25~35 inhibited IA in neonatal rat hippocampal CA3 pyramidal neurons and displayed a time-,concentration- and voltage-dependent manner;the dynamic characteristics of IA were influencedshifted the steady-state activation and inactivation curves to left significantly.Conclusion These results suggest that the inhibition of unaggregated A?25-35 on transient outward potassium channel in acutely isolated hippocampal CA3 pyramidal neurons may be an important mechanism of its toxicity,which participates in pathological changes of AD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Medical Research
Année:
2006
Type:
Article
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