Endostatin:antiangiogenic properties and the therapeutic effect on rheumatoid arthritis / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Article
Dans Chinois
| WPRIM
| ID: wpr-565264
ABSTRACT
Neovascularization is one of the early pathologic changes of rheumatoid arthritis(RA)synovium and is the major players in the promotion and perpetuation of pannus.Endostatin has antiangiogenic effect via inhibition of endothelial cell proliferation,migration and induction of apoptosis.The inhibition of angiogenesis in synovium by endostatin appears to be a promising means for the future treatment of RA.Also,endostatin has a therapeutic effect on RA by the inhibition of proliferation and induction of apoptosis in fibroblast-like synoviocytes.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmacological Bulletin
Année:
1987
Type:
Article
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