Effects of Estradiol on the Chronic Periodontitis in Experimental Rat / 医学研究杂志

ABSTRACT

Objective In this research,the relationship between blood estrogen level and periodontitis in rats was studied. Methods Twenty-four female Wister rats were randomly divided into three groupscontrol group,sham operation group and ovariectomized group. Rat chronic periodontitis model was established by ligating the rat's second molar with a steel wire in the sham operation group and ovariectomized group. Serum estrogen level of the rats was detected respectively. Dental X-ray observation,histological examination and immunohistochemistry were employed for the characterization of rat's chronic periodontitis. Results Compared with both control group and sham operation group,a significant decrease in scrum estrogen level was observed in ovariectomized group (P