Antidiarrheal and Anti-inflammatory Effects or Oxypeucedanin / 中草药

ABSTRACT

Oxypeucedanin (OP) 300 and 600mg/kg ig inhibited the increased permeability of intraperitoneal blood capillary induced by ip 0. 7% acetic acid in mice, xylene-induced swelling of mouse ear, retarded gastrointestinal propellant rate of charcoal ink in normal mice,and reduced the incidence and frequency of purging induced by castor oil or senna in mice. These actions were enhanced in a dose-dependent manner. It is suggested that the antidiarrheal effect of OP is relative to its restriction against inflamation and gastrointestinal propellant function.