Apoptosis of human fetal glomerular endothelial cell induced by neutrophil proteinase 3 from ANCA positive children with SLE / 中华风湿病学杂志
Chinese Journal of Rheumatology
;
(12)2000.
Article
Dans Chinois
| WPRIM
| ID: wpr-569671
ABSTRACT
Objective To investigate whether the neutrophil serine proteinase 3 (PR 3),a specific autoantigen of C ANCA,could induce human fetal glomerular endothelial cell apoptosis in vitro .Methods PR 3 was isolated from polymorphonuclear leukocytes obtained from C ANCA positive children with SLE.The cultured glomerular endothelial cells from human fetal kidneys were treated with PR 3 and apoptosis was assessed by different methods including the propidium iodide staining,DNA fragmentation analysis,and morphology observation.Results Percentage of apoptotic cells significantly increased ( P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Rheumatology
Année:
2000
Type:
Article
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