Clinical study of sulindac in the treatment of sporadic colorectal adenomas / 中华消化杂志

ABSTRACT

Objective To investigate the effects of su lindac on sporadic colorectal adenomas. Methods Thirty-six patients diagnosed as sporadic colorect al adenomas colonoscopically and pathologically were randomly divided into t wo groups. The study group took 400 mg of sulindac daily and the control group w ere given placebo both for 4 months. Changes of number, size, figure and degree of atypia of adenomas were compared before and after treatment. Results Sixteen patients in each group finished the trial. In the study group, the average diameter of 59 adenomas before and after the treatment was (3.6?2.2) mm and (2.4?1.5) mm, respectively. The difference was statist ica lly significant (P0.05) nor were the changes in figure and degree of atypia of adenomas. Conclusions Sulindac is effective in the reduction of size and a typ ia degree of adenomas in patients with sporadic colorectal adenomas but the long term effects of sulindac in patients with sporadic colorectal adenomas should b e observed.