Effect of rosiglitazone on insulin resistance and hyperandrogenism in polycystic ovary syndrome / 中华妇产科杂志

ABSTRACT

Objective To evaluate the effect of rosiglitazone on insulin resistance and hyperandrogenism in polycystic ovary syndrome (PCOS) Methods Rosiglitazone was given 4 mg daily to 30 patients with PCOS for 12 weeks Before and after treatment, body mass index(BMI), plasma glucose, insulin, levels insulin resistance index (HOMA IR), blood lipid spectrum, leptin, neuropeptide Y, and sex hormone concentrations and ovulation rate were determined and compared Results After 12 weeks of treatment, basal insulin level decreased from (18?8) to (12?7) mIU/L ( P