Antineutrophil autoantibodies and their target antigens in lupus nephritis / 中华风湿病学杂志

ABSTRACT

Objective To investigate the target antigens and their clinical association with antineutrophil autoantibodies in patients with lupus nephritis (LN).Methods Sera were collected from 92 renal biopsy proven LN patients.Normal neutrophils and white cells from patients with chronic granulocytic leukemia (CGL) were used as antigens in Western blot analysis to detect autoantibodies in the LN sera.Results ①Using neutrophils as antigens,two bands could be blotted64 000 (33/92,35 9%)and 50 000 (13/92,14 1%).The prevalence of anti 64 000 autoantibody in patients with positive rheumatic factor was significantly higher than that in patients without (54 5% vs 18 8%, P