Experiment on pharmadynamics and acute toxicity of Sanyuzhitong Pills / 中成药

ABSTRACT

Objective: To study the pharmadynanics and acute-toxicity of Sanyuzhitongjiegu Pills Methods: Hot plate, body-twisted, in flammation caused by dimethyl benzene, cotton ball method, fracture-healed hare and hemorrheology were applied. Results: Sanyuzhitongjiegu Pills could markedly reduce the twisting times of mice and prolong the initiate of pain caused by heat irritation, inhibit mice's ear swelling caused by dimethyl benzene, diminish the weight of rat's myoidem, promote the healing of experimental fracture, reduce the sticky property of whole blood and improve hemorrheology. The maximum of dosage for mice is 10g?kg -1 , all of them survived for 7 day. Conclusion: Shayuzhitong Pills have effect on pain-killing, anti-inflammation, promotion of fracture healing, regulation of blood, remove of stagnant, The Pills have little toxicity.