The alert role of Clara cell secretory protein in serum from patients in the developing course of acute respiratory distress syndrome / 重庆医科大学学报

ABSTRACT

Objective:To search for a prophetic marker reflecting the progress of acute respiratory distress syndrome (ARDS).Methods:The serum was obtained from normal controls and patients at difierent stages of ARDSsystemic inflammatory response syndrome (SIRS),acute lung injury(ALI),ARDS and just before dying.Clara cell secretory protein (CC16) in serum was detected using enzyme-linked immunoadsordent assay (ELISA).Results:In the early stage of inflammatory reaction,that is,stage of SIRS,the CC16 levels in serum were higher than normal controls ( P 0.01).Conclusion:The determination of CC16 in serum is a sensitive marker reflecting the integrity of alveolar epithelium and vascular endothelial cell.The alteration of CC16 is presented in the early period of acute inflammatory reaction.The alteration of CC16 is earlier than that of blood gas analysis.CC16 may serve as a helpful marker to foresee and evaluate prognosis of ARDS in early stage.