Study on analgesic effect of rofecoxib on patients with advanced carcinoma / 重庆医科大学学报

ABSTRACT

Objective:To study the analgesic effect of rofecoxib on patients with advanced carcinoma.Methods:In a randomized clinical trial,108 pathologically diagnosed cancer patients were treated with rofecoxib(dose 25～50mg/d) and the pain relief was observed among all the patients.Results:Rofecoxib was effective in control of cancer related pain in an oral dose of 25～50mg/day with a total effective rate of 84.26%.The main adverse reactions such as drowsiness,dizziness,nausea,vomiting,discomfort in stomach and constipation were slight.Conclusion:Rofecoxib is effective for relieving cancer related pain with sustained duration and slight in adverse reaction and convenient for administration.