The effects of topiramate and valproate sodium on spontaneous motor activity behavior and isolation-induced aggression in mice / 重庆医科大学学报

ABSTRACT

Objective:To study the effects of valproate sodium and topiramate on spontaneous motor activity behavior and isolation-induced aggression in mice,and thus to provide evidence for drug treatment.Methods:Male Kunming mice were isolated for 40～45days as an animal model of isolation-induced aggression.The isolated and group-housed mice were administrated with different doses of valproate sodium (0mg/kg、50mg/kg、100mg/kg、200mg/kg) and topiramate(0mg/kg、25mg/kg、50mg/kg、100mg/kg).The aggressiveness of isolated mice was measured 30min after the administration of valproate sodium or 120min after the administration of topiramate.Results:Valproate sodium and topiramate could dose-dependently prolong the latencies to attacking.They could also decrease spontaneous motor activity.Conclusion:Both valproate sodium and topiramate are inhibitors of aggression behavior in isolated mice.Topiramate and valproate sodium have synergism.