The inhibitory effect of cyclooxygenase inhibitor on human breast cancer line MDA-MB-231 in vitro / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1986.
Article
Dans Chinois
| WPRIM
| ID: wpr-573979
ABSTRACT
Objective:
To investigate the inhibitory effect of cyclooxygenase inhibitor acetylsalicylic acid(ASA),and a selective COX-2 inhibitor(Nimesulide) on the growth of human breast cancer cell line MDA-MB-231 in vitro.Methods:
The inhibitory effect was detected by MTT assay.Immunohistochemical assay was performed to examine the expressions of COX-2 and c-erbB-2 in SKOV3 cell line treated by NSAIDs.Results:
A decrease in cell number compared with controls was observed in all of the cell line treated with ASA and Nimesulide.It was a dose-dependent inhibition of cell proliferation.COX-2 was expressed positive in MDA-MB-231 and the expression of cerbB-2 was found to decrease by immunohistochemical assay.Conclusion:
NSAIDs can inhibit the growth of human breast cancer cell line MDA-MB-231 in vitro.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Chongqing Medical University
Année:
1986
Type:
Article
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