Effective components combination of Xiaoxuming Decoction on anti-Alzheimer’s disease / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
Dans Zh
| WPRIM
| ID: wpr-574131
Responsable en Bibliothèque :
WPRO
ABSTRACT
AIM: To apply high throughput screening methods to research Xiaoxuming Decoction's effective components combination and its action mechanism. METHODS: We studied the effects of 240 sequential components of Xiaoxuming Decoction (L1-L120,A1-A120) on anti-A? neurotoxicity、anti-H_2O_2 damage、anti-glutamic acid damage and ?-secretase activity. RESULTS: We evaluated these results of screening comprehensively,and found several components of Xiaoxuming Decoction (L1-L40,A30-A60,A100-A120) had the potential effects of listed before.So the combination of these components was regarded as the effective components combination of Xiaoxuming Decoction for anti-Alzheimer's disease. CONCLUSION: Xiaoxuming Decoction had effective protection against Alzheimer's disease through multi-component and multi-target.High throughput screening methods will push the development of Chinese traditional compound prescription greatly.
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WPRIM
langue:
Zh
Texte intégral:
Chinese Traditional Patent Medicine
Année:
1992
Type:
Article