Influence of CTLA4Ig combined with rapamycin on the survival of renal allografts in rats / 重庆医科大学学报

ABSTRACT

Objective:To study the influence of Costimulatory Blockade CTLA4Ig combined with rapamycin(RPM)on the survival of renal allografts in rats.Methods:BN→Lewis rat kidney transplantation was performed.The recipients were grouped into group1(control),group2(CTLA4Ig),group3(rapamycin,RPM) and group4(CTLA4Ig+RPM).The survival of renal allografts,serum creatinine of the recipients and the pathological changes of the allografts were observed.Results:Significantly prolonged allografts survival time was seen in group 2,3 and 4 compared with control,with the longest in group 4.The lowest serum creatinine and fewest lymphocytes infiltrating grafts were also seen in group4.Conclusion:Combined use of CTLA4Ig and rapamycin(RPM)may suppress renal allograft rejection effectively and promote further prolongation of the survival of renal allografts.