High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea
The Korean Journal of Parasitology
;
: 201-204, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-57429
ABSTRACT
Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has suggested that T. gondii infection is associated with development of brain tumors. However, in Korea, epidemiological data regarding this correlation have been scarce. In this study, in order to investigate the relationship between T. gondii infection and brain tumor development, we investigated the seroprevalence of T. gondii among 93 confirmed brain tumor patients (various histological types, including meningioma and astrocytoma) in Korea using ELISA. The results revealed that T. gondii seropositivity among brain tumor patients (18.3%) was significantly (P<0.05) higher compared with that of healthy controls (8.6%). The seropositivity of brain tumor patients showed a significant age-tendency, i.e., higher in younger age group, compared with age-matched healthy controls (P<0.05). In conclusion, this study supports the close relationship between T. gondii infection and incidence of brain tumors.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Toxoplasma
/
Encéphale
/
Tumeurs du cerveau
/
Test ELISA
/
Études séroépidémiologiques
/
Incidence
/
Microenvironnement tumoral
/
Corée
/
Méningiome
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
The Korean Journal of Parasitology
Année:
2016
Type:
Article
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