Research on expression of CTGF in myocardial interstitial remodeling in infracted rat model / 重庆医科大学学报

ABSTRACT

Objective: To discuss the expression of CTGF in myocardial tissue during myocardial remodeling and to understand the molecular mechanism of myocardial remodeling after myocardial infarction.Methods: Twenty four SD rats were randomly divided into two groups sham group and infracted group.In infracted group left anterior descending coronary artery was ligated for 8 weeks but not in sham group.Collagen protein of myocardial tissue was tested with chemistry to understand myocardial interstitial remodeling.CTGF protein were studied with immunohistochemistry analysis.CTGF mRNA expression was tested by reverse transcription and polymerase chain reaction(RT-PCR).Results: Expressions of CTGF protein and mRNA were significantly enhanced(P