Effect of Salvia miltiorrhiza Bge on glucocorticoid-induced osteoporois in rats / 中成药

ABSTRACT

AIM:To study the (rat's) osteoporosis induced by long-term administration of prednisone,and investigate the prophylactic effects of Salvia miltiorrhiza Beg in male rats. METHODS: Twenty-four SD rats were randomly divided into four groups such as control group,prednisone group and Danshen(Salvia miltiorrhiza Bge) group,with 8 rats per group.control group was treated with normal saline,other groups with prednisone at dose of(2.7) mg/kg first,and then prednisone group with normal saline group with Salvia miltiorrhiza Bge at dose of 5.0 g/kg,respectively,once a day for 12 weeks.At the experimental endpoint,bone histomorphometric analysis of thighbone were performed in undecalcified sections,the contet of Ca~(2+) and oxyproline hydroxyproline of ulnar bone were to be measured.length and width of the thighbone were to be tested. RESULTS: Bone histomorphometric parameters showed bone loss was significant to prednisone group(P