The effect of hyaluronic acid on anti-inflammatory action in mouse
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 16-22, 2010.
Article
de Ko
| WPRIM
| ID: wpr-57599
Bibliothèque responsable:
WPRO
ABSTRACT
PURPOSE: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1beta(IL-1beta), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. MATERIAL AND METHODS: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply). RESULTS: Hyaluronic group showed less expressions of IL-1beta, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope. CONCLUSION: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
ARN messager
/
Dinoprostone
/
Expression des gènes
/
Cytokines
/
Oreille
/
Oedème
/
Électrons
/
Acide hyaluronique
/
Inflammation
/
Lumière
Limites du sujet:
Animals
langue:
Ko
Texte intégral:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Année:
2010
Type:
Article