Preparation of self-microemulsifying soft capsule and investigation of dissolution for pueraria lobata isoflavone / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
Dans Zh
| WPRIM
| ID: wpr-576941
Responsable en Bibliothèque :
WPRO
ABSTRACT
AIM:
In order to prepare the self-microemulsifying soft capsule(SMESC)of pueraria lobata isoflavone and investigate its dissolution property.METHODS:
Through solubility experiment,self-microemulsification in vitro,phase diagram and the stability of solution,the optimum formulation was selected for pueraria lobata isoflavone.The dissolution of SMESC was measured taking the commercial tablet as reference.RESULTS:
In the selected formulation,Tween-80,1,2-Propanediol and ethyl oleate were screened as emulsifier,co-emulsifier and oil phase,respectively.The optimized proportion was 65∶20∶15 .The dissolution of SMESC in the condition of distilled water,pH6.8 phosphate buffer and 0.1 mol/L HCl were more than 90% in 10 min,while those of the commercial tablet were less than 40% in 90 min.CONCLUSION:
In comparison with the commercial tablet,the dissolution of pueraria lobata isoflavone is sufficiently improved at various conditions.
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Traditional Patent Medicine
Année:
1992
Type:
Article