Effect of Chaihu Shugan Powder and Xiaoyao Powder on Serum Corticosterone and Gastrointestinal Hormones of Chronic Multi-stress Rats / 中药新药与临床药理

ABSTRACT

Objective To observe the content changes of corticosterone and gastrointestinal hormones in serum of chronic multi-stress rats and to investigate the effect of Xiaoyao Powder and Chaihu Shugan Powder.Methods Wistar rats were randomly allocated to four groupsnormal group(group A),model group(group B),Xiaoyao Powder group(group C),Chaihu Shugan Powder group(group D)etc.Chronic multi-sress models were established in all the rats except those of normal group.Xiaoyao Powder group and Chaihu Shugan Powder group were respectively given the corresponding drugs for 21 days.Normal group and model group were administered the equal amount of normal saline by gavage.After the administration,the open-field test was used to observe the behavior changes of the rats,and the radioimmunoassay method was adopted to detect the serum corticosterone and gastrin contents and plasma motilin level.Results Compared with the normal group,the body weight of model group was decreased(P