Bioavailability of Silymarin-loaded Nanoparticles / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
de Zh
| WPRIM
| ID: wpr-577884
Bibliothèque responsable:
WPRO
ABSTRACT
AIM:To study the oral bioavailability of Silymarin-loaded Nanoparticles(SM-NP). METHODS: Beagle dogs were employed as experiment animals,Yiganling Tablet and Silymarin Extraction were used as the reference preparations.Three constituents were isolated on Ultimate~(TM) AQ-C_(18) column with mobile phase methanol:water(50∶50) at 0.8 mL/min flow rate using gradient elution and ESI ionic source and negative ion detection.Silybin plasma concentration in rat was determined by LC-M. RESULTS: The pharmacokinetics of the tested preparation and Yiganling Tablet met with one-compartment model.The relative bioavailability of three components of SMNP were higher than that of Yiganling Tablet. CONCLUSION: The results indicate that SM-NP has better bioavailability than the reference preparation,which confirms that nanoparticles is a good carrier for improving oral bioavailability of poorly-soluble drugs.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Traditional Patent Medicine
Année:
1992
Type:
Article