Effect of Tianma Gouteng Decoction on Myocardial Fibrosis in Spontaneously Hypertensive Rats / 广州中医药大学学报
Journal of Guangzhou University of Traditional Chinese Medicine
;
(6)2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-578625
ABSTRACT
Objective To investigate the effect of Tianma Gouteng Decoction(TGD) on myocardial fibrosis in spontaneously hypertensive rats(SHR) and to explore its possible mechanism. Methods Twenty-four male SHR with 8 weeks old were equally randomized into three groups TGD(20g/kg) group,captopril(100mg/kg)positive group and the model group.Eight Wistar Kyoto rats(WKY) with the same age served as the controls.The systolic blood pressure(SBP),left ventricular mass(LVM),left ventricular mass index(LVMI),myocardial collagen(MC) content in left ventricle of three groups were determined after treatment for 24 weeks.Meanwhile,the expression of myocardial insulin-like growth factor 1(IGF-1) was determined by reverse transcription-polymerase chain reaction(RT-PCR) assay.Results TGD had an effect on decreasing the SBP,LVM,LVMI,MC content and IGF-1 expression(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Essai clinique contrôlé
/
Étude pronostique
langue:
Chinois
Texte intégral:
Journal of Guangzhou University of Traditional Chinese Medicine
Année:
2004
Type:
Article
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