Effect of Niaodu Qing Capsule and Its Separated Prescriptions on Renal TGF?_1 mRNA Expression in Rats After 5/6 Nephrectomy / 广州中医药大学学报
Journal of Guangzhou University of Traditional Chinese Medicine
;
(6)2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-578824
ABSTRACT
Objective To observe the effect of Niaodu Qing Capsule(NQC) and its separated prescriptions on renal transforming growth factor ?1(TGF-?1)mRNA expression in rats with chronic renal failure(CRF).Methods SD rat models of CRF were induced by 5/6 nephrectomy,and then the CRF rats were randomized into model group,Huangqi(Radix Astragali,1.5 g?kg-1?d-1) group,Danshen(Radix Salviae Miltiorrhizae,1 g?kg-1?d-1) group,Dahuang(Radix et Rhizoma Rhei,1 g?kg-1?d-1) group,Huangqi Danshen Dahuang(1 g?kg-1?d-1) group,NQC group(1 g?kg-1?d-1).Except the model group,the rats in other groups received gastric gavage of corresponding medicine according to the experimental design.After treatment for six weeks,the levels of blood urea nitrogen(BUN) and serum creatinine(SCr) were detected,and the expression level of renal TGF-?1 mRNA was examined by reverse transcription polymerase chain reaction(RT-PCR).Results The levels of BUN and SCr were decreased in the medicated groups(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Essai clinique contrôlé
/
Étude pronostique
langue:
Chinois
Texte intégral:
Journal of Guangzhou University of Traditional Chinese Medicine
Année:
2004
Type:
Article
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